Laron syndrome and immunity to cancer and diabetes
Keywords:
Dwarfism, - IGF-1 - Diabetes - GH Hormone – Cancer.Abstract
The Laron syndrome or Laron-type Dwarfism, aSLo called Growth Hormone Insensitivity, is a rare, congenital, autosomal recessive disease that does not present differences of affectation by sex. More than 350 cases of the disease have been described worldwide, especially in the Mediterranean (Israel, Saudi Arabia, Egypt and Iraq) and with the highest incidence in Ecuador, specifically in the province of Loja where 75% of the total is found cases worldwide. The objective is to document the genetic bases involved in the pathophysiology and development of the disease, as well as its association with cancer and diabetes mellitus in the Ecuadorian population. The methodological framework includes a documentary design, through a systematic bibliographic search of full-text articles, published in the last ten years in journaSL indexed in the scientific databases and search engines PubMed, MEDLINE, Cochrane, Google Scholar, Scielo, Scopus, Redalyc, Elsevier and WOS. It is expected to show the most relevant genotypic and phenotypic characteristics in the Ecuadorian population, as well as possible theories in pathophysiology and its association with a lower risk of developing diabetes and cancer.
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