Lung involvement and biomarkers associated with SARS-Cov-2 disease progression
DOI:
https://doi.org/10.59169/pentaciencias.v5i3.576Keywords:
SARS-CoV-2; COVID-19; lung disease; biomarkers; comorbidities.Abstract
In December 2019, an outbreak of acute respiratory infection due to a novel coronavirus was detected in Wuhan, China. By the end of December, this disease had spread to other locations in China and the world. In February 2020, China's public health authorities recognized the new disease as coronavirus 2019 (COVID-19) caused by SARS-CoV-2 virus. In order to analyze the pulmonary involvement and biomarkers associated with the progression of the SARS-CoV-2 virus disease, a descriptive and exploratory documentary research design was carried out through a literature search in scientific databases such as PubMed, SciELO, Elsevier, Google Scholar, Redalyc, Springer and other official sources such as the Pan American Health Organization (PAHO), World Health Organization (WHO) books, and health reports. In conclusion, the main pulmonary abnormalities were peribronchial thickening, ground glass opacities, vascular congestion, pulmonary fibrosis, the most prevalent comorbidities that influenced the severity of the disease were diabetes, The most prevalent comorbidities influencing disease severity were diabetes, arterial hypertension, cardiovascular disease and renal disease. As for biomarkers, D-dimer, CRP, LDH, lymphocyte count, procalcitonin, ferritin and IL-6 had the highest correlation with patient severity.
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Abdel Hamid, H. M., Rizk, H. I., & Magdy, S. (2021). Occurrence of pulmonary residuals as one of the sequelae of COVID-19 and it’s predictors among moderate and severe cases. Indian Journal of Tuberculosis, 68(4), 450–456. https://doi.org/10.1016/J.IJTB.2021.01.006
Álvarez-Maldonado, P., Hernández-Ríos, G., Ambríz-Mondragón, J. C., Gordillo-Mena, J. A., Morales-Serrano, D. F., Reding-Bernal, A., & Hernández-Solis, A. (2021). Características y mortalidad en pacientes mexicanos con COVID-19 y ventilación mecánica. Gaceta Medica de Mexico, 157(1), 97–101. https://doi.org/10.24875/GMM.20000568
Amancio Castro, A., & del Carpio Flórez, S. (2021). Relación entre las comorbilidades y la morbilidad y la mortalidad en la COVID-19. Anales de la Academia de Ciencias de Cuba, 11(2), 1–6. http://scielo.sld.cu/scielo.php?pid=S2304-01062021000200025&script=sci_arttext&tlng=en
Arentz, M., Yim, E., Klaff, L., Lokhandwala, S., Riedo, F. X., Chong, M., & Lee, M. (2020). Characteristics and Outcomes of 21 Critically Ill Patients with COVID-19 in Washington State. En JAMA - Journal of the American Medical Association (Vol. 323, Número 16, pp. 1612–1614). American Medical Association. https://doi.org/10.1001/jama.2020.4326
Blanco, J. R., Cobos Ceballos, M. J., Navarro, F., Sanjoaquin, I., Arnaiz de las Revillas, F., Bernal, E., Buzon-Martin, L., Viribay, M., Romero, L., Espejo-Perez, S., Valencia, B., Ibañez, D., Ferrer-Pargada, D., Malia, D., Gutierrez Herrero, F. G., Olalla, J., Jurado-Gamez, B., & Ugedo, J. (2021). Pulmonary long-term consequences of COVID-19 infections after hospital discharge. Clinical Microbiology and Infection, 27(6), 892–896. https://doi.org/10.1016/j.cmi.2021.02.019
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. The Lancet, 395(10223), 507–513. https://doi.org/10.1016/S0140-6736(20)30211-7
Delgado Guillen, K., Cedeño Ubillús, M., Zambrano Mendoza, A., Morán Loor, W., Carranza Dominguez, A., & Mendoza Santos, M. (2021). Factores asociados a la mortalidad de los pacientes atendidos por covid-19 en el servicio de urgencias. Ciencia Latina Revista Científica Multidisciplinar, 5(5), 8799–8813. https://doi.org/10.37811/cl_rcm.v5i5.955
Díaz Rubia, L., Pérez Naranjo, P., Miras Ventura, J. A., & Sánchez Torrente, A. (2022). Tromboembolismo pulmonar en pacientes con infección por COVID-19 en nuestro centro. Seram, 1(1). https://www.piper.espacio-seram.com/index.php/seram/article/view/8442
Ena, J., & Wenzel, R. P. (2020). Un nuevo coronavirus emerge. Revista Clínica Española, 220(2), 115–116. https://doi.org/10.1002/jmv.25682.3.
Escobar Perez, K., Sapon Lopez, B., & Ixcot Perez, C. (2022). Vista de Caracterización de los biomarcadores en COVID19 moderado a grave en pacientes pediátricos. Revista Médica, Colegio de Médicos y Cirujanos de Guatemala., 161(1), 2664–3667. https://www.revistamedicagt.org/index.php/RevMedGuatemala/article/view/436/634
Escobar Salinas, J., Duarte, L., Sobarzo Vysokolan, P., & Ferreira Samudio, M. L. (2022). Biomarcadores inflamatorios asociados a mortalidad en pacientes con neumonía a Sars-Cov-2. Revista del Instituto de Medicina Tropical, 17(1), 35–43. https://doi.org/10.18004/IMT/2022.17.1.5
Fink, N., Rueckel, J., Kaestle, S., Schwarze, V., Gresser, E., Hoppe, B., Rudolph, J., Goller, S., Kunz, W. G., Ricke, J., & Sabel, B. O. (2021). Evaluation of patients with respiratory infections during the first pandemic wave in Germany: characteristics of COVID-19 versus non-COVID-19 patients. BMC Infectious Diseases, 21(1), 1–11. https://doi.org/10.1186/S12879-021-05829-X/TABLES/3
Franco Escobar, V. D., Morales Chorro, L., Baltrons Orellana, R., Rodríguez, C. R., Urbina, O., & López de Blanco, C. (2021). Mortalidad por COVID-19 asociada a comorbilidades en pacientes del Instituto Salvadoreño del Seguro Social. Alerta, Revista científica del Instituto Nacional de Salud, 4(2), 28–37. https://doi.org/10.5377/alerta.v4i2.10366
Frija Masson, J., Debray, M. P., Gilbert, M., Lescure, F. X., Travert, F., Borie, R., Khalil, A., Crestani, B., D’Ortho, M. P., & Bancal, C. (2020). Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection. En European Respiratory Journal (Vol. 56, Número 2). European Respiratory Society. https://doi.org/10.1183/13993003.01754-2020
Grasselli, G., Zangrillo, A., Zanella, A., Antonelli, M., Cabrini, L., Castelli, A., Cereda, D., Coluccello, A., Foti, G., Fumagalli, R., Iotti, G., Latronico, N., Lorini, L., Merler, S., Natalini, G., Piatti, A., Ranieri, M. V., Scandroglio, A. M., Storti, E., … Pesenti, A. (2020). Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA - Journal of the American Medical Association, 323(16), 1574–1581. https://doi.org/10.1001/jama.2020.5394
Grassi, R., Belfiore, M. P., Montanelli, A., Patelli, G., Urraro, F., Giacobbe, G., Fusco, R., Granata, V., Petrillo, A., Sacco, P., Mazzei, M. A., Feragalli, B., Reginelli, A., & Cappabianca, S. (2021). COVID-19 pneumonia: computer-aided quantification of healthy lung parenchyma, emphysema, ground glass and consolidation on chest computed tomography (CT). Radiologia Medica, 126(4), 553–560. https://doi.org/10.1007/S11547-020-01305-9/FIGURES/2
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
Jiménez, D. L. C. B., Padrón, H. M., García, L. E. V, Valdés, A. R., Del Campo, N. S., Orozco, A. P., & Moya, L. I. R. (2020). Morbilidad por COVID-19: análisis de los aspectos epidemiológicos, clínicos y diagnósticos. Revista Cubana de Medicina Tropical, 72(3), 1–14. http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0375-07602020000300005
Lippi, G., & Plebani, M. (2020). Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis. Clinica Chimica Acta, 505, 190–191. https://doi.org/10.1016/j.cca.2020.03.004
López Bauzá, Á., & Rodríguez Portal, J. A. (2022). Afectación pulmonar tras la infección aguda por SARS-CoV-2. Open Respiratory Archives, 4(2), 100–117. https://doi.org/10.1016/j.opresp.2022.100167
Martin Rosa, C., Mereles, S., Wiersba, V., Valenzuela, J., Frassa, M., Princz, M., TisiBaña, M., Alvarez, J., Pratesi, P., Bonorino, J., Rodriguez, M., Brenzoni, P., Colimodio, P., & Aris Cancela, M. E. (2022). Valor pronóstico del dímero D al ingreso en pacientes COVID-19. Revista Hematología, 26(1). http://www.revistahematologia.com.ar/index.php/Revista/article/view/433
Ministerio de Salud Publica. (2023). Situación coronavirus Covid-19. https://www.salud.gob.ec/actualizacion-de-casos-de-coronavirus-en-ecuador/
Mogollon Hurtado, S., Sosa, A., Blanco, E., Gomez Duque, M., Mendoza, O., Polo, J., & Parra Medina, R. (2022). Hallazgos histopatológicos pulmonares en COVID-19. Experiencia en autopsias mínimamente invasivas. Repertorio de medicina y cirugia, 31(1), 46–52. https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1348/2097
Motta, J. C., Novoa, D., Gómez, C. C., Moreno, J., Vargas, L., P#x00E9;rez, J., Mill#x00E1;n, H., & Arango, #x00C1;lvaro Ignacio. (2020). Factores pronósticos en pacientes hospitalizados con diagnóstico de infección por SARS-CoV-2 en Bogotá, Colombia. Biomedica, 40(2), 116–130. https://doi.org/10.7705/BIOMEDICA.5764
Núñez-Cortés, R., Ortega-Palavecinos, M., Soto-Carmona, C., Torres-Gangas, P., Concha-Rivero, M. P., & Torres-Castro, R. (2021). Determinantes sociales de la salud asociados a la severidad y mortalidad en pacientes con COVID-19. Gaceta Medica de Mexico, 157(3), 273–280. https://doi.org/10.24875/GMM.20000778
Ojha, V., Mani, A., Pandey, N. N., Sharma, S., & Kumar, S. (2020). CT in coronavirus disease 2019 (COVID-19): a systematic review of chest CT findings in 4410 adult patients. European Radiology, 30(11), 6129–6138. https://doi.org/10.1007/S00330-020-06975-7/TABLES/4
Organización Mundial de la Salud(OMS). (2023). Brote de enfermedad por coronavirus (COVID-19). https://www.paho.org/es/temas/coronavirus/brote-enfermedad-por-coronavirus-covid-19
Organization, W. H. (2020). Pneumonia of unknown cause – China. Disease outbreak news. https://www.who.int/emergencies/disease-outbreak-news/item/2020-DON229
Pachar L., J., Rodríguez D., G., Pachar F., M., Saldaña, L., & López-Verges, S. (2021). Hallazgos pulmonares en un caso de muerte inesperada por infección de COVID-19. Revista Española de Medicina Legal, 47(1), 41–44. https://doi.org/10.1016/J.REML.2020.08.001
Ramos Rojas, M. C., Cuaresma Cuadros, E. A., Cayo Castillo, J. J., & Monasterio Benique, D. A. (2022). Asociación de biomarcadores y severidad de COVID-19: estudio transversal. Medwave, 22(6), 1–11. https://doi.org/10.5867/medwave.2022.06.002548
Saad, E. J., Barovero, M. A. C., Marucco, F. A., Bonazzi, S. T. R., Barra, A. T., Zlotogora, M., Villada, S. M., Barrionuevo, A. D. y, Heredia, M. C., Caeiro, J. P., Fernández, P., & Albertini, R. A. (2021). Características clínicas y epidemiológicas de pacientes hospitalizados por infección por SARS-CoV-2 en dos hospitales en Córdoba Infección por SARS-CoV-2 en pacientes hospitalizados. Revista de la Facultad de Ciencias Médicas, 78(3), 303. https://doi.org/10.3105310.31053/1853.0605.v78.n3.32518
Statista Research Department. (2023). Coronavirus en Latinoamérica: países con más casos. https://es.statista.com/estadisticas/1105121/numero-casos-covid-19-america-latina-caribe-pais/
Tuttolomondo, D., Frizzelli, A., Aiello, M., Bertorelli, G., Majori, M., & Chetta, A. (2022). Beyond the lung involvement in COVID-19 patients. Minerva medica, 113(3), 558–568. https://doi.org/10.23736/S0026-4806.20.06719-1
Ugas Charcape, C. F., Ucar, M. E., Almanza Aranda, J., Rizo Patrón, E., Lazarte Rantes, C., Caro Domínguez, P., Cadavid, L., Pérez Marrero, L., Fazecas, T., Gomez, L., Sánchez Curiel, M., Pacheco, W., Rizzi, A., García Bayce, A., Bendeck, E., Montaño, M., Daltro, P., & Arce V, J. D. (2021). Pulmonary imaging in coronavirus disease 2019 (COVID-19): a series of 140 Latin American children. Pediatric Radiology, 51(9), 1597–1607. https://doi.org/10.1007/S00247-021-05055-2/TABLES/4
Vélez Páez, J. L., Pelosi, P., Battaglini, D., & Best, I. (2023). Biological Markers to Predict Outcome in Mechanically Ventilated Patients with Severe COVID-19 Living at High Altitude. Journal of Clinical Medicine, 12(2), 644. https://doi.org/10.3390/JCM12020644
Vences, M. A., Pareja, J., Otero, P., Veramendi-Espinoza, L., Vega-Villafana, M., Mogollón-Lavi, J., Morales, E., Olivera-Vera, J., Salas, L., Triveño, A., Marin, R., Carpio-Rodriguez, R., & Zafra, J. (2020). Factores asociados a mortalidad en pacientes hospitalizados con COVID-19: Cohorte prospectiva en el Hospital Nacional Edgardo Rebagliati Martins. Scielo Preprints, 12(1), 1–23. https://doi.org/10.1590/SciELOPreprints.1241
World Health Organization (WHO). (2020). WHO Director-General’s opening remarks at the Mission briefing on COVID-19 - 16 April 2020. WHO. https://www.who.int/director-general/speeches/detail/who-director-general-s-opening-remarks-at-the-mission-briefing-on-covid-19---28-may-2020
Wu, Z., & McGoogan, J. M. (2020). Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China. JAMA - Journal of the American Medical Association, 323(13), 1239–1242. https://doi.org/10.1001/jama.2020.2648
Xie, J., Tong, Z., Guan, X., Du, B., & Qiu, H. (2020). Clinical Characteristics of Patients Who Died of Coronavirus Disease 2019 in China. JAMA network open, 3(4), e205619. https://doi.org/10.1001/jamanetworkopen.2020.5619
Xie, J., Tong, Z., Guan, X., Du, B., Qiu, H., & Slutsky, A. S. (2020). Critical care crisis and some recommendations during the COVID-19 epidemic in China. Intensive Care Medicine, 46(5), 837–840. https://doi.org/10.1007/s00134-020-05979-7
Xiong, S., Liu, L., Lin, F., Shi, J., Han, L., Liu, H., He, L., Jiang, Q., Wang, Z., Fu, W., Li, Z., Lu, Q., Chen, Z., & Ding, S. (2020). Clinical characteristics of 116 hospitalized patients with COVID-19 in Wuhan, China: a single-centered, retrospective, observational study. BMC Infectious Diseases, 20(1), 1–11. https://doi.org/10.1186/s12879-020-05452-2
Yazdi, N. A., Ghadery, A. H., SeyedAlinaghi, S. A., Jafari, F., Jafari, S., Hasannezad, M., Koochak, H. E., Salehi, M., Manshadi, S. A. D., Meidani, M., Hajiabdolbaghi, M., Ahmadinejad, Z., Khalili, H., Mehrabi Nejad, M. M., & Abbasian, L. (2021). Predictors of the chest CT score in COVID-19 patients: a cross-sectional study. En Virology Journal (Vol. 18, Número 1, pp. 1–8). BioMed Central Ltd. https://doi.org/10.1186/s12985-021-01719-5
Yupari-Azabache, I., Bardales-Aguirre, L., Rodriguez-Azabache, J., Shamir Barros-Sevillano, J., & Rodríguez-Diaz, Á. (2021). Factores de riesgo de mortalidad por covid-19 en pacientes hospitalizados: un modelo de regresión logística. Rev. Fac. Med. Hum. Enero, 21(1), 19–27. https://doi.org/10.25176/RFMH.v21i1.3264
Zanforlin, A., Strapazzon, G., Falk, M., Gallina, V., Viteritti, A., Valzolgher, L., La Guardia, M., Ferro, F., Pagani, L., & Vezzali, N. (2021). Lung Ultrasound in the Emergency Department for Early Identification of COVID-19 Pneumonia. Respiration, 100(2), 145–153. https://doi.org/10.1159/000512782
Zhan, T., Liu, M., Tang, Y., Han, Z., Cheng, X., Deng, J., Chen, X., Tian, X., & Huang, X. (2020). Retrospective analysis of clinical characteristics of 405 patients with COVID-19. Journal of International Medical Research, 48(8), 1–10. https://doi.org/10.1177/0300060520949039
Zhang, J. jin, Dong, X., Cao, Y. yuan, Yuan, Y. dong, Yang, Y. bin, Yan, Y. qin, Akdis, C. A., & Gao, Y. dong. (2020). Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy: European Journal of Allergy and Clinical Immunology, 75(7), 1730–1741. https://doi.org/10.1111/all.14238
Zhang, L., Yan, X., Fan, Q., Liu, H., Liu, X., Liu, Z., & Zhang, Z. (2020). D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. Journal of Thrombosis and Haemostasis, 18(6), 1324–1329. https://doi.org/10.1111/jth.14859
Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, 395(10229), 1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3
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